Endocrine Abstracts

The insidious onset of symptoms and slow progression of acromegaly often results in a delay in diagnosis for several years. We report an unusual case who presented with progressive lymphoedema of the lower limbs 25 years before the diagnosis of acromegaly became apparent.A 51 year old lady presented to the surgical outpatient clinic with a twenty four year history of bilateral leg swelling and hypertension of 21 years duration. There was no antecedent h...

Objective: Insulin-like growth factor-II (IGF-II), a critical regulator of placental development, enhances proliferation and survival of human cytotrophoblasts by signalling through the IGF-1 receptor (IGF-1R). Excess IGF-II binds to IGF-2R, which mediates its transport to the lysosomes for degradation. Although considered to act solely as an IGF-II clearance receptor, IGF-2R has been implicated in mediating IGF-II-stimulated migration and invasion in trophoblast. We therefore...